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Emulate, Inc. is a pioneering Organ-Chip company dedicated to overcoming the limitations of traditional animal studies and reductionist models in life science research. Emulate developed the Human Emulation System, which features living human in vitro models known as microphysiological systems (MPS) or Organ-Chips, enabling researchers to understand and predict human response.
Using the Revolve microscope, Emulate runs Organ-Chip studies to reduce translational failure and improve human disease research. The Revolve has significantly improved the labs workflow, allowing them to image and annotate in real-time directly on the scope quickly and efficiently.
Emulate integrates Revolve into many aspects of their daily workflow, including for imaging their Duodenum Intestine-Chip model.
For Emulate’s model, the team images biopsy-derived primary duodenal organoids in the top channel, and small intestinal microvascular endothelial cells in the bottom channel of their Chip-S1 Stretchable Chip.
Swipe through to see the images Emulate captured of their Duodenum Intestine-Chip model with Revolve.
Brightfield image showing the two channels separated by a porous membrane, enabling cross-talk between the two compartments.
Emulate uses their Revolve microscope for various imaging needs, allowing them to capture high-resolution images and perform regular imaging checks with ease.
Morphological changes are analyzed in cells to assess drug-induced effects on the chip.
For quick fluorescent imaging of primary and secondary staining on PFA-fixed chips.
Uses Revolve to image their kidney model, Albumin (a fluorescent stain), which evaluates drug absorption capabilities, to study drug absorption dynamics.
For Emulate’s duodenum model, organoids are imaged to study structural characteristics.
During the cell seeding process, chips are inspected with Revolve to ensure proper seeding density.
Watch this video to see how Emulate uses their Revolve microscope to run studies of their Organ-on-a-Chip technology, accelerating the adoption of more human-relevant science and reduce the reliance on animal models.
“Its user-friendly design and high-resolution capabilities have cut our imaging time in half!
I highly recommend ECHO microscopes to anyone looking for publication-quality images, whether in phase contrast or fluorescence, straight from the scope.
Plus, the iPad integration makes it seamlessly compatible with our Macs, making sharing and editing far easier than other systems that require file conversions.”
Explore how Emulate and our other customers are using the Revolve microscope for impactful research through our Publication Database.
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See how other customers use ECHO microscopes in their workflows to help accelerate their research and drive science forward.