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ECHO Applications
Tiling, also called tile scanning or large-area imaging, allows researchers to capture a mosaic of adjacent fields of view that are automatically stitched into one seamless, high-resolution image. It is essential when a single field of view cannot capture the full extent of a sample: whole slides, tissue sections, organoid arrays, and multi-well plates all demand tiling to reveal the complete biological picture.
We’ve developed our microscopes to make tiling fast, intuitive, and frustration-free. The ECHO Revolution is our high-throughput widefield tiling platform supporting up to 4 slides, while the ECHO Confocal adds high sensitivity and minimal photobleaching (compared to point scanning systems) to the same seamless tiling workflow.
Captured with Revolution
Captured with ECHO Confocal
Researchers shouldn’t spend hours trying to produce a beautiful stitched image. Traditional microscopes cause issues at every numerous steps of a Tiling workflow. Here’s how ECHO changes that.
Traditional systems send tiles to offline software for stitching, forcing researchers to wait before they can even see their data.
Mismatched illumination and poor tile registration leave ugly seams that compromise image quality and analysis.
Most tiling systems require extensive training before a user can confidently set up, acquire, and process a tiled dataset.
Opening massive tiled datasets in competing software can freeze programs and interrupt collaborative review sessions.
ECHO stitches tiles in real time — the seamless image is ready the moment acquisition is complete, zero waiting.
ECHO's tile blending software produces a perfectly continuous mosaic every time — publication-ready out of the box.
An intuitive interface walks users through tiling setup in minutes — ideal for core facilities and new lab members alike.
ECHO's software loads even massive tiled files dramatically faster than competing platforms — no freezes, no lag.
Hyperscan enables ultra fast scanning and mosaic image stitching at high-speed camera frame rates in Brightfield and Fluorescence. High-Speed predictive focus tracking and real-time shading correction enable rapid and clear acquisitions.
Revolution and Confocal synchronize brushless linear servo motors with camera triggering for high-speed continuous scanning.
Scan your entire samples in seconds, then revisit areas of interest.
Conventional tiling microscopy can leave visible stitch lines and illumination inconsistencies between tiles. These artifacts distract from the science and require additional multiple post processing steps to correct.
ECHO’s proprietary stitching engine blends tiles in real time, producing a continuous, uniform image the moment acquisition ends. This means no post-processing or seam lines. (Available with Revolution and ECHO Confocal)
The Hunsberger Lab uses the Revolution microscope for a wide range of projects in the lab.
With their interest in neurodegeneration, the lab examines brain regions, including the hippocampus, prefrontal cortex, and amygdala, which become dysfunctional in disease.
Using the Revolution microscope, the team analyzes cell activation, measures differences between groups, and creates correlational heat maps between brain regions to determine network differences. Tiling helps create beautiful images for them to take deeper dives into.
This system provides you with rapid imaging abilities due to it's spinning disk and has one of the smallest confocal footprints on the market.
Perfect for high-speed tiling in brightfield and fluorescence in widefield. Can be operated in both upright and inverted configurations.
Our award-winning service team is available and can offer on-site, phone, or video support. Please contact or chat us so we can help.
Yes, we provide both virtual and in-person training for our customers. Additionally, every microscope is preloaded with our interactive iBooks manual. This is a great training tool for new lab members or as an easy refresher for existing users.
We have microscopy specialists globally available for technical questions, product demonstrations, and support. Please contact or chat us so we can help.
Yes, we offer both virtual and onsite product demonstrations of our microscopes. We follow CDC guidelines for masking and social distancing during our in-person demos. Please schedule a demo to schedule a demo for your lab.
Upright microscopes are only capable of viewing glass slides. Inverted microscopes are optimized to view live and fixed samples in well plates, dishes, and flasks. Our microscopes’ ability to easily convert from an upright to an inverted means that your microscope can be optimized for each sample.
Our microscopes are optimized to view samples and cells prepared on slides, well plates, petri dishes, flasks, and hemocytometers.
We work with Chroma Technologies and offer all the standard filters sets from UV to Cy7. We can also provide custom filter sets to fit your specific applications. Please contact or chat us.
We offer a 1-year warranty. We also offer extended warranty packages.
Software updates are free and easily installed through the App Store.
Yes, we work with and can recommend several finance companies to help you structure a lease option that works best for your timing and budget. We are also happy to work with your finance company as well. Please contact or chat us.
Yes, please contact or chat us us so we may send you a list of publications in your field of research.
We believe pricing should be transparent. Try our quote builder to build and price your own system.
Please contact or chat us.
We offer a full solution ideal for keeping your sample healthy over a long period of time. Specifically we control temperature, CO2, humidity, and can accommodate hypoxia conditions.
Yes you can easily take the incubation box off the microscope. The entire box is one piece and slides out from the front.
Yes, our incubator is box style which keeps all the optical components in the same thermal conditions and shields the system from the outside environment. We also offer autofocus which will find the focus of your samples for your desired channel and hold that over time.
Our incubation is offered on the Revolution microscope.
Yes, you can easily add full incubation to your Revolution microscope after it is installed.
Want to see our microscopes in action? Schedule an in-person demo for your samples or a quick 10-minute virtual demo.