Starting a new lab or interested in current promotions? Check out our limited time offers.
The Hunsberger Lab at Rosalind Franlkin University of Medicine and Science investigates why women are more susceptible to Alzheimer’s disease (AD), how mood disorders impact aging and disease, and how life experiences shape the aging brain. Ultimately, they aspire to function as a translational lab, using basic science to answer clinically driven questions.
The Revolution microscope allows the lab to image brain tissue at confocal-level resolution, supporting their research into Alzheimer’s disease, aging, and sex differences.
To answer the lab’s questions, the Hunsberger Lab uses transgenic AD mice, a diverse array of behavioral paradigms, immediate-early gene tagging, chemogenetics, in vivo calcium imaging and the Revolution microscope. These mice findings are compared against large human datasets, helping translate laboratory research into human relevance.
Brain-wide imaging plays a central role in this work, revealing how brain regions, circuits, and cells are altered in disease.
The Revolution microscope has supported a wide range of projects in the lab, including studies on:
With their interest in neurodegeneration, the lab examines brain regions, including the hippocampus, prefrontal cortex, and amygdala, which become dysfunctional in disease.
Using the Revolution microscope, the team analyzes cell activation, measures differences between groups, and creates correlational heat maps between brain regions to determine network differences.
Swipe through to see images captured on the Revolution microscope.
Parvalbumin inhibitory interneurons (green) and c-fos (magenta) within the dCA3 of the mouse brain.
Parvalbumin inhibitory interneurons (green) and c-fos (magenta) within the vCA1 of the mouse brain.
Parvalbumin inhibitory interneurons (green) and c-fos (magenta) within the dDG of the mouse brain.
Microglia (red, Iba1) surrounding plaques (blue, methoxy-04) in an APP/PS1 mouse.
The Revolution microscope gives the Hunsberger Lab flexibility to run experiments and image on their own schedule, achieving confocal-level resolution without relying on a core facility, saving both time and money.
Quickly captures high-resolution images of tissue sections.
Touchscreen and measurement tool aids in testing new viral injection coordinates into the brain with precision.
Small enough to fit in lab’s space, with freedom to image on demand.
Shared across multiple labs within the Center, Revolution supports collaboration with each team using the scope for their own work.
The Hunsberger Lab featured Revolution in their publication, Alprazolam induces anterograde amnesia for contextual fear memory and alters dorsoventral hippocampal neuronal ensembles in female mice.
In the figure to the right, the lab imaged tissue sections on the Revolution microscope at 10× magnification, revealing that Alprazolam alters ventral hippocampal ensembles in female but not male mice.
Explore how the Hunsberger Lab and other customers are using ECHO microscopes for impactful research through our Publication Database.
Starting at $70,051 or finance for as low as $1,477/month.
Visit FAQs or compare with our other microscopes
See how other customers use ECHO microscopes in their workflows to help accelerate their research and drive science forward.